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Valepsy Syrup 100ml
- Sodium Valproate, the active ingredient, is an anti-epileptic medication. Its mechanism of action is not fully understood but is believed to increase brain levels of gamma-aminobutyric acid (GABA), which has inhibitory effects on nerve activity, helping to control seizures.
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✅ Description:
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✔️ Valepsy is used to treat various types of epilepsy, including:
- Partial seizures
- Absence of seizures (petit mal)
- Generalized tonic-clonic seizures (grand mal)
- Myoclonic seizures
- Atonic seizures
- Mixed seizures, including absence attacks
- Prophylaxis of febrile convulsions
- Prophylaxis of post-traumatic epilepsy
Additionally, it is used in the treatment of bipolar disorder and for the prophylaxis of migraine.
✔️ Composition:
- Sodium Valproate Tablets: Each enteric-coated tablet contains 200 mg of Sodium Valproate BP.
- Sodium Valproate Syrup: Each 5 ml syrup contains 200 mg of Sodium Valproate BP.
- Sodium Valproate Controlled-Release Tablets:
- 200 mg tablet contains 133.2 mg Sodium Valproate & 58 mg Valproic acid.
- 300 mg tablet contains 199.8 mg Sodium Valproate & 87 mg Valproic acid.
- 500 mg tablet contains 333 mg Sodium Valproate & 145 mg Valproic acid.
- Sodium Valproate Injection: Each 5 ml injectable solution contains 500 mg of Sodium Valproate (equivalent to Valproic Acid 500 mg).
✔️ Side Effects: Valepsy Syrup
- Common: Anorexia, nausea, vomiting, sedation, ataxia, tremor, rash, alopecia, increased appetite.
- Hepatic effects: Elevated liver enzymes in plasma, potential for fulminant hepatitis, particularly in children under 2 years or those on multiple antiepileptic drugs.
- Pancreatitis and hyperammonemia may also occur.
✔️ Dosage: Valepsy Syrup
Epilepsy:
- Adults: Start with 600 mg daily (divided doses), increasing by 200 mg/day at 3-day intervals up to a maximum of 2.5 g/day.
- Children (over 20 kg): Start with 400 mg daily, increasing to control seizures (max 35 mg/kg/day).
- Children (up to 20 kg): Start with 20 mg/kg/day in divided doses.
Febrile Convulsions: 20-30 mg/kg/day in divided doses.
Bipolar Disorder: Start with 600 mg daily in 2-3 divided doses; maintenance dose is 1000-2000 mg/day.
Migraine Prophylaxis: 400-600 mg daily, with some requiring 1000-1500 mg/day.
✔️ Interaction:
Sodium Valproate may inhibit drug metabolism and interact with medications like Phenobarbital, Phenytoin, Warfarin, and Aspirin.
✔️ Contraindications:
- Hypersensitivity to Sodium Valproate or liver dysfunction.
- Not recommended for pregnant women or women of childbearing potential.
✔️ Pregnancy & Lactation:
- Pregnancy: Valproate is associated with neural tube defects (e.g., spina bifida) if taken during the first trimester. Women should be offered screening for α-fetoprotein levels.
- Lactation: Excreted in breast milk, but no significant risk to infants has been observed.
✔️ Precautions & Warnings:
- Monitor liver function before and during the first 6 months, especially for at-risk patients.
- Exercise caution in cases of renal impairment, pregnancy, breastfeeding, and systemic lupus erythematosus.
- Avoid sudden withdrawal of therapy, which could cause seizures.
✔️ Storage:
Store below 30°C, away from light and out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
